How To Suppress Inflammation for COPD and RA Patients with Stem Cell Therapy?
Stem cell therapy for rheumatoid arthritis and COPD provides long-term relief from the pain and complications related to the condition.
There are more than 24 million Americans who are affected with chronic obstructive pulmonary disorder while millions of others are suffering from rheumatoid arthritis.
Mesenchymal stem cells have been actively used to treat conditions similar to RA and COPD with different models. The results are more than satisfactory in treating and reversing the conditions of the diseases.
Recently, stem cell treatment has brought a new ray of hope for providing relief to humans.
Table of Contents
What is Rheumatoid Arthritis?
Rheumatoid arthritis is a chronic autoimmune disorder in which the immunity system of the body attacks its own protective layers of the joint. Also, RA affects the vascular, bone, metabolic, and psychological factors of the body.
Additionally, RA can cause further complications like cardiac issues, pulmonary diseases, and renal damage.
Symptoms of RA –
- Joint pain and stiffness
- Inflammation of the joint
- Weight and appetite loss
- Fever and sweating
The immune system of RA patients attacks its own protective joint layers. Moreover, people with higher variations of genetic factors such as human leukocyte antigen have more probability of developing this condition.
Causes of RA –
- Individuals of any age can suffer from RA
- Women suffer from rheumatoid arthritis more than man
- Smoking increases the risk of RA
- Overweight people have higher chances of suffering from RA
What is Lung Fibrosis?
Lung fibrosis is a chronic disease of the lungs or the pulmonary tracts. It falls under the bracket of COPD and reduces your breathing abilities. The respiratory tract cells and tissues are collaterally damaged. The tissues thicken over time and limit the functions of the heart.
More than 200,000 US citizens live with lung fibrosis and it is one of the leading causes of mortality rate.
This condition is more prevalent in men than women and affects people within the age group of 50-70 years.
Signs of lung fibrosis –
- Short breath during activities
- Dry and persistent cough
- Weight loss and tiredness
- Loss of appetite
- Clubbing of feet
- Joint and muscle pain
Causes of lung fibrosis –
- Radiation treatment
- Exposure to harmful chemicals and toxins
- Prevalent autoimmune diseases
- Affinity to inflammation
- Smoking
- Genetics
- Age
What is COPD?
COPD causes inflammation in the lungs, blocks the respiratory tracts, and causes a wide range of pulmonary sub-diseases like asthma and bronchitis.
Inflammation in the air tracts or the respiratory passage blocks the free flow of air and oxygen to the lungs. This causes suffocation. The air sacs in the lungs that help to breathe in and out are also damaged due to COPD.
It eliminates the elastic abilities of the air sacs and leads to long-term breathing problems.
Signs of COPD are –
- Running out of breath
- Wheezing sounds while breathing
- Congestion in the chest
- Too much mucus secretion
- Recurrent cough
- Infections in the respiratory tracts
- Low energy levels
- Swelling of the feet
- Cyanosis or bluish lips
Leading COPD causes –
- Inflamed and thickened airway walls
- Lost elasticity of the air sacs in the lungs
- Damage to the air sac walls
- More mucus in the airway blocking airflow
- Air pollution and environmental toxins causing breathlessness
MSCs for COPD are self-healing treatments for the lungs and related tissues for improved air, oxygen, and blood circulation.
[Read Also: Transform Your Health with Advanced Stem Cell Therapy in Dallas]
Importance of Embryonic Stem Mesenchymal Stromal Cells in Reducing Inflammation
Mesenchymal stem cells are cultured from Wharton’s Jelly found in the umbilical cord of healthy newborn babies. These are tested and sourced in the laboratory and differentiated from human embryonic stem-cell derived-MSCs in vitro. It helps to regenerate T-cells rapidly and offers protection against cell infiltration.
Collagen-induced arthritis (CIA) models have been tested with hESC-MSCs in an intravenous administration method to successfully reduce inflammation conditions. Moreover, it improves the protection of T cells against infiltration and promotes activation. The CIA model is the most preferred model for treating humans with RA. This is a widely accepted model due to the local and immunological similarities of RA in humans.
Similarly, a bleomycin-induced lung fibrosis model was treated with hESC-mesenchymal stromal cells in an intravenous (IV) approach. MSC treatment eliminates the root causes and underlying symptoms of lung fibrosis.
The therapeutic results of MSCs are undeniable, creating a new avenue for holistic and surgery-free treatment.
Apart from reducing inflammation, the regenerative and immunomodulatory properties of MSCs make it a popular choice for treating a wide range of diseases and injuries.
Benefits of Stem Cell Treatment
Mesenchymal stem cell treatment offers a wide range of benefits against inflammation and related symptoms. MSCs can reverse the effects of RA and lung fibrosis and provide long-term relief from the disastrous effects of these diseases. Results from clinical trials highlight significant development in the condition of patients suffering from inflammation related to RA and lung fibrosis. In a broader spectrum, let us explore the benefits of MSCs in reducing inflammation further –
- Increases regulatory T cells
- Decreases inflammatory Th1 cells
- Decreases pro-inflammatory cytokines like interferon, interleukin, and IL17
- Increases anti-inflammatory cytokines like growth factor-beta and interleukin 10
- Abundant supply of stem cells
- Eliminates the chances of cell rejection
- MSCs have high regenerative abilities compared to other types of stem cells
- Rapid repair and quick results
- Toxin-free MSCs
- Minimally-invasive technique compared to painful surgeries
- Regeneration of lung tissues and blood vessels to clear the air pathway for free breathing
- Stem cells can split into protective membranes and connective tissues
- Removes carbon dioxide and circulates oxygen in the air tracts
[Read Also: How To Treat Premature Ovarian Failure with Mesenchymal Stem Cell Therapy?]
Bottomline
Mesenchymal stromal cells can successfully reduce inflammation of the joints and the lungs. The treatment offers relief from pain and inflammation. Moreover, it ensures the free flow of blood in the air sacs and forms the protective layers of the affected joints.
The hESC-MSC are successfully tested and show considerable improvement in the conditions of millions of patients. Similarly, due to the equivalent restorative and healing abilities, MSCs are used to treat RA and COPD conditions as well.
The Life Altering Stem Cell Therapy Institute is an American-owned and operated clinic with state-of-the-art infrastructure and certified doctors.
We provide a holistic, painless, and direct administration method (IV, IA, or IM) to treat patients with stem cell therapy.
Breathe and move freely with the ideal stem cell treatment for your condition. Talk to our experts for detailed solutions.
Stem Cell Therapy for COPD Management: A New Hope
Research shows that nearly 5% of the world’s population suffers from Chronic Obstructive Pulmonary Disorder (COPD), and it is the third leading cause of death worldwide. This prevalent lung disease affects men and women equally, resulting in poor quality of life. Although treatments are limited, significant developments in regenerative medicine, mainly stem cell therapy, offer hope to millions battling this progressive lung disease.
This article explores the revolutionary treatment for COPD that has emerged recently, focusing on the potential of stem cells to repair damaged lung tissues and reduce inflammation.
Table of Contents:
Understanding Chronic Obstructive Pulmonary Disorder (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is a group of respiratory diseases that results in lung inflammation and narrowing of the airways. COPD encompasses debilitating conditions such as emphysema or chronic bronchitis that damage the lung tissues and cause difficulty breathing.
While traditional treatments focus on managing symptoms by slowing disease progression, the damage to the lungs is irreversible, and it can recur in the future, limiting the patient’s ability to do simple daily tasks. Symptoms of COPD include shortness of breath, chronic cough with phlegm, breathing problems, tiredness, wheezing, pressure in the chest, frequent respiratory infections, and fatigue.
Cigarette smoking is the prime cause of COPD, as 70% of COPD cases in high-income countries are due to excessive smoking. Other than this, long-term exposure to toxic pollutants like chemical fumes, air irritants, and specks of dust also contribute to the development of COPD in patients.
Read Also: Stem Cell Basics: What They Are And How Do They Work
The Emergence of Stem Cell Therapy For COPD Management
Preclinical studies and research suggest that stem cell therapy can alleviate the symptoms and manage COPD. Mesenchymal stem cells’ anti-inflammatory and immunomodulatory properties can help repair inflamed lung tissues and restore lung function. Further, their regenerative capabilities can self-renew and regrow healthy tissue to interact with the host environment, accelerating the healing response.
Stem cells are undifferentiated immature cells found in the human body that have the power to develop and multiply into any cell type. Clinics use these cells to prepare stem cell injections to treat various health conditions, from chronic obstructive pulmonary disorder (COPD), to cardiovascular disease, autoimmune disorders, and orthopedic injuries. In the context of COPD, the stem cells administered into the patient’s body differentiate into lung-specific cells, such as alveolar and bronchial cells, to promote tissue regeneration.
How Mesenchymal Stem Cells Address Tissue Repair and Regeneration
Stem cells exert their therapeutic effects in COPD management through different mechanisms, from paracrine signaling to immunomodulation and anti-inflammation to tissue regeneration. This multifaceted approach to treating respiratory diseases eliminates the pathological processes and promotes lung repair.
- Paracrine Signaling – The newly infused stem cells release signaling molecules and bioactive factors, such as cytokines, chemokines, growth factors, and extracellular vesicles. These paracrine factors affect the surrounding cells in the damaged tissue and promote regenerative processes.
- Immunomodulation – MSCs have immunomodulatory properties that suppress the excessive growth and activation of immune cells that contribute to lung inflammation. The stem cells play a vital role in shifting the immune response from pro-inflammatory immune cells to anti-inflammatory agents, promoting the proliferation of regulatory T cells (White blood cells that control immune response).
- Anti-inflammatory effects – Stem cells directly secrete anti-inflammatory molecules such as TGF – β and IL – 10 to counteract the inflammation and suppress the activity of immune cells and inflammatory mediators.
- Tissue regeneration – The stem cells differentiate into lung cell types, such as endothelial, epithelial, bronchial, and alveolar cells, which replace or repair the diseased cells and contribute to tissue regeneration for functional recovery.
In summary, stem cells’ therapeutic effects directly dampen inflammation of lung tissues, prevent further damage, and simultaneously create a favorable host environment for healthy and faster tissue repair and regeneration. Once they reach the damaged area in the lungs, they trigger cell-to-cell interaction with the neighboring cells and the extracellular matrix to activate the secretion of paracrine factors.
Scientists believe this multifaceted mechanism of stem cells is effective in cell proliferation and differentiation, modulating immune system behavior, and stimulating angiogenesis. However, more research and knowledge are necessary to understand the dynamic connection between stem cells and the host environment in lung tissue repair and regeneration.
Improvements Observed in Patients After Stem Cell Therapy
The patients receiving stem cells for COPD have reported significant improvements in their symptoms and enhanced quality of life. They have experienced reduced difficulty in breathing, improved lung capacity, and relieved symptoms like coughing and shortness of breath. Stem cell therapy for COPD suppresses inflammation in the lung tissues, improves permeability, and reduces oxidative stress. Patients also experience a regain in their exercising ability, increased strength in muscles and bones, better weight control, and decreased risk of cardiovascular diseases.
Future Perspectives Stem Cells in COPD Treatment
Continued research and clinical trials on stem cells for COPD management pave the way for more advanced therapies, addressing all the significant challenges and optimizing their effectiveness. The future of stem cells holds great promise, and ongoing exploration of its advancements is expected to shape the future of COPD treatment.
One of the emerging trends in the field is advanced cell engineering, which boosts the therapeutic potential of mesenchymal stem cells. Researchers aim to modify stem cell properties through gene editing and manipulation and optimize their regenerative capabilities, tailoring them to the precise needs of COPD patients and reprogramming stem cells to make them patient-specific induced pluripotent stem cells, offering the possibility of personalized stem cell treatments.
Read Also: Stem Cell Treatment: Recent Advancements And New Applications
Key Takeaway
With the rapid pace of scientific advancements in the stem cell field, the concept of a cure for Chronic Obstructive Pulmonary Disorder (COPD) seems no longer a dream. Stem cell therapy shows promising results in regenerating damaged lung tissues and improving the lives of millions of COPD patients. The application of stem cells shows positive outcomes by relieving symptoms and managing respiratory disease effectively.
Patients wondering where to get the best stem cell therapy can contact Life Altering Stem Cell Therapy Institute. Our well-established stem cell center in Mexico provides advanced treatments and the best hospitality experiences in a homely atmosphere. We are well-equipped with cutting-edge technologies and an experienced team of stem cell experts, ensuring swift recovery and positive outcomes in less time.
