What is the Conditional Diagnosis?

Healthcare providers can diagnose POF by applying the following techniques –

• Pregnancy Test – A pregnancy test to determine if the candidate is eligible to conceive and deliver babies. Also, to determine if the women missed their menstrual cycle or got irregular periods.
• Physical Exam – Physical tests are conducted to check signs of disorders or diseases that could be present in the female. Addison’s disease is one such example that can be detected with the help of this test.
• Blood Samples – Blood samples are collected to test for follicle-stimulating hormone, estrogen levels, luteinizing hormone levels, and karyotype tests.
• Pelvic Ultrasound – A pelvic sonogram test gives an internal view of the woman’s ovaries highlighting unnatural ovary growth or multiple follicles.

Signs and Causes of Premature Ovarian Failure

Multiple symptoms indicate premature ovarian failure in women. The inability to conceive and early menopause are the leading signs. However, let us walk you through the details of the symptoms –

Symptoms

Noteworthy symptoms of POF –

• Irregular or missed menstrual cycle for 4 months at a stretch
• Lowered levels of estrogen
• Enhanced follicle-stimulating hormone levels
• Trouble and incapability towards pregnancy
• Reduced sexual drive
• Mood fluctuations assisted with
• Disturbed memory and concentration
• Night sweats
• Neurological disorders such as disputed cognitive abilities, Parkinson’s disease, dementia, and speech loss
• Estrogen deficiency weakens bone health density

[Read Also: Transform Your Health with Stem Cell Therapy in Miami ]

Causes

Top causes of POF –

• Changes in the Chromosome – Chromosomes contain genes that distinguish the gender of a person at birth. Females have two X chromosomes. However, women with insufficient X chromosomes have one altered type of X chromosome that can be fragile. This condition is fragile X syndrome.
• Exposure to Toxins – Radiation-based therapies used to treat patients with cancer can induce toxins into the ovary causing insufficiency. Genetic materials in the cells are destroyed due to these strong treatment techniques. Environmental toxins such as chemicals, cigarette smoke, and viruses can lead to POF.
• Response of the Immune System to Ovarian Tissue – The immune system develops protective proteins that attack the ovary tissue mistakenly. Ovary follicles or eggs are damaged.
• Unprecedented Factors – Idiopathic diseases that affect a female without any proper source or cause can enhance premature ovarian failure.
• Lifestyle – Several lifestyle factors such as poor nutritional intake, lack of sleep, excessive use of tobacco, and lack of physical activities can aggravate the condition.

What is the Equivalent Medical Condition for Males?

Infertility issues are not only limited to women but also affect a large number of the male population. Erectile dysfunction is the leading infertility issue in men. It can affect any man regardless of their age. Long-term persistence of this condition can lead to impotence. It physically limits a man’s ability to have sex organ erections.

Erectile dysfunction can lead to a wide range of heart and health diseases such as diabetes. Other than this, leading causes of ED include hypertension, low testosterone levels, obesity, cardiovascular diseases, and psychological causes such as stress and depression.

Nevertheless, advanced erectile dysfunction treatments with stem cell therapy provide relief and boost confidence in men significantly.

Here are the benefits of choosing stem cell therapy for POF –

• Improved tissue and cell regeneration for enhanced blood flow
• Improves the sensitivity of the sexual organ to enhance performance
• A minimally invasive and painless administration technique with fast recovery results
• Best-quality human umbilical cord mesenchymal stem cells are administered to ensure zero rejection chances

Importance of Mesenchymal Stem Cells for Premature Ovarian Failure Treatment

Stem cells can reverse the limited functionalities of the ovarian endocrine system and restore fertility in women.

Mesenchymal stem cells have several therapeutic effects. It can improve the overall functioning of the ovaries and reduce the signs and causes of GC apoptosis. Moreover, mesenchymal stem cell therapy can boost the following for women with premature ovarian failure –

1. Improves folliculogenesis
2. Enhances the rate of GC apoptosis
3. Accelerates vascular formation
4. Regulates the level of hormones
5. Improves the chances of pregnancy
6. Restores the menstrual abilities
7. Decreases FSH levels
8. Increases AMH levels
9. Improves ovarian weight
10. Ability to differentiate egg cells
11. Enhance the production of estrogen and progesterone

Results of Stem Cell Therapy

Before we explore the results related to stem cell therapy for premature ovarian failure, let us navigate the administration techniques for stem cells.

Administration Technique

The stem cells are administered applying intravenous (IV) techniques where an injection is introduced in the ovary region. The process takes 4-5 days to complete. However, different administration techniques are followed for different patients depending on their age, weight, and condition.

Treatment Results

POF Treatment results with stem cells include –

• Improved fertility – Ability to get pregnant and healthy formation of eggs.
• Enhanced sexual drive – Increased hormonal activities leading to natural sexual capabilities.
• Regeneration of healthy hormones – Repair, replacement, and regeneration of healthy estrogen.
• Repaired ovarian tissues – Repaired ovarian follicles and tissues for better functioning.
• Prevention of infertility causes in the future – Prevents the recurrence of POF in women in the future and ensures a healthy ovarian system.

What is Male Infertility?

The World Health Organization (WHO) defines male infertility in humans as the inability to fertilize their female partners through unprotected and regular intercourse for 12 months or more. As per the latest statistics, over 30 million couples worldwide are facing infertility issues, with the highest numbers observed in African and Eastern European nations. Although infertility is associated with both men and women, almost 20% to 30% of couples experience difficulty in conceiving due to male infertility.

A decline in the sperm count over time, the diminished quality of the sperm, and abnormal blockages or functioning of the reproductive system result in infertility in men. Male infertility is one of the primary reasons for social distress among couples and their families, alongside mental and financial burdens. Hence, early diagnosis of the problem and proper medical intervention are necessary.

Types and Causes of Male Infertility

Male infertility can be of various types based on the causes and fertility parameters. Let’s understand each of the types and associated symptoms.

Erectile Dysfunction (ED) – It is a type of infertility disorder that occurs when a man is unable to maintain a firm erection that is long enough for sexual intercourse. Partners of patients with ED often face difficulty achieving pregnancy. Reduced sexual drive, difficulty getting an erection, difficulty keeping the erection, and unsatisfied sex are the common symptoms of erectile dysfunction.

Azoospermia – Azoospermia is a reproductive disorder in men characterized by the complete absence of sperm in the fluid after ejaculation. It happens because the testicles are unable to produce or release mature sperm. Prominent symptoms of Azoospermia are erectile dysfunction, swelling or lump around testicles, decreased hair on the body and face, and lower sexual desire.

Hypogonadism – Male hypogonadism is the body’s inability to produce enough testosterone, resulting in infertility and sexual problems. Testosterone is the hormone responsible for masculine growth and proper functioning of the reproductive organs in men. Reduced sex drive and erectile dysfunction are the effects of hypogonadism in males.

Other than biological reasons, various lifestyle and environmental factors also affect the fertility of a man, such as exposure to toxins, excessive smoking and alcohol drinking, obesity, anxiety issues, emotional stress, and depression. The next segment of this article sheds light on the potential of stem cells in treating male infertility and improving patient’s quality of life.

What are Spermatogonial Stem Cells?

Spermatogenesis is the process of developing male gametes or sperm cells by the testes. Spermatogonial stem cells (SSCs) are rare adult stem cells found in the male body that are crucial for maintaining the healthy spermatogenesis process. SSCs are considered the foundation of the male reproductive system and male fertility.

Spermatogonial stem cells are found in the basal membrane of seminiferous tubules and undergo cellular mitosis to promote differentiation, self-renewal, and formation of sperm cells. These cells play a critical role in maintaining a stable stem cell pool by developing mature spermatozoa over time.

Role of Mesenchymal Stem Cells In Promoting Spermatogonial Stem Cells

Mesenchymal stem cells (MSCs) are immature cells present in specific tissues in the human body and can differentiate and multiply into any cell type. They are also known as stromal cells, which help form organ or gland-specific cells or tissues by providing support and structure. They are found in the bone marrow, adipose or fat tissue, embryos, or umbilical cord tissue.

Several studies demonstrate that mesenchymal stem cells derived from human umbilical cord tissue have remarkable potential to grow into germ cells and address male infertility. Stem cell therapy using MSCs has been, therefore, a promising treatment to improve sperm count and sperm quality in patients suffering from infertility issues.

Spermatogenesis is a stem-cell-based mechanism where unspecialized stem cells differentiate into sperm cells to restore the functioning of male reproductive organs. Spermatogonial stem cells produced through cell differentiation of mesenchymal stem cells are used as a therapeutic alternative to treat impaired spermatogenesis and enhance fertility preservation.

How Does Spermatogonial Stem Cell Therapy Treat Male Infertility?

Cellular therapy using spermatogonial stem cells is a revolutionary treatment alternative for infertility issues in men, such as non-obstructive Azoospermia and impaired spermatogenesis. Stem cells regenerate healthy cells to replace the damaged spermatogenesis and restore fertility. SSCs are unique adult cells that can self-renew or regrow cells that will genetically contribute to future generations.

Recent studies have demonstrated that human SSCs have pluripotent properties and can differentiate into all cell lineages, including the three germ cell layers. Spermatogonial stem cell therapy helps in cell differentiation and growth of spermatozoa to help restore fertility. These cells contribute to creating a conducive microenvironment and growth factor stimulation.

Safety and Efficacy of the Stem Cell Therapy

Stem cell therapy for infertility treatment is typically safe and effective with no potential side effects. Also, numerous human studies and clinical trials indicate that results are satisfactory, with significant improvements in patients in terms of increased sex drive, better erection, and better sperm count and quality.

Though these findings demonstrate stem cell therapy as a safer alternative to traditional clinical treatments for male infertility, more research is needed to enhance its success rates and evaluate the potential risks.

Best Place to Get Stem Cell Therapy For Erectile Dysfunction

If you are seeking a reliable stem cell center in Mexico to treat male infertility due to erectile dysfunction, Life Altering Stem Cell Therapy Institute is a name you can always trust. We specialize in offering personalized stem cell therapy to every patient by addressing their unique problems and their underlying causes.

Our advanced stem cell therapy for erectile dysfunction has given hope to countless couples who are keen to start or expand their families. Connect with our medical team or visit our clinic in Mexico to start your journey towards enhanced fertility.